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Green tea can prevent prostate cancer
Publish Date : 12/2/2004 2:14:00 PM   Source : Health News Onlypunjab.com

A new research to be published  in  the
journal 'Cancer Research' has found that the polyphenols  present
in green tea help prevent the spread of prostate cancer.
 
They  do  so by targeting molecular pathways that shut  down  the
proliferation  and spread of tumour cells, as well as  inhibiting
the growth of tumour nurturing blood vessels.
The researchers from the University of Wisconsin, documented  the
role  of green tea polyphenols (GTP) in modulating  the  insulin-
like growth factor-1 (IGF-1)-driven molecular pathway in prostate
tumour cells in a mouse model for human prostate cancer.
 
They  found that the consumption of GTP led to reduced levels  of
IGF-1. It was also found that GTP also led to increased levels of
one of the binding proteins for IGF-1, the insulin growth  factor
binding protein-3. These observations bear significance in  light
of studies that indicate increased levels of IGF-1 are associated
with increased risk of several cancers, such as prostate, breast,
lung and colon.
 
GTP  also  caused  reduced expression of  proteins  known  to  be
associated  with  the  metastatic spread  of  cancer  cells.  GTP
inhibited  the levels of urokinase plasminogen activator as  well
as  matrix metalloproteinases 2 and 9, cellular molecules  linked
to the metastasis.
 
The  green  tea  polyphenols  contributed  to  minimizing  tumour
development  by  governing  the amount  of  vascular  endothelial
growth  factor (VEGF) in the serum of the prostate  cancer  mouse
model. (ANI)